Product info:

This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.

Alternative names:

FGD1; AAS; FGDY; MRXS16; ZFYVE3; FYVE

Species reactivity:

Mouse, Rat

Host:

Rabbit

Cellular localisation:

Cell projection, Cytoplasm, cytoskeleton, lamellipodium, ruffle

Isotype:

IgG

Immunogen:

A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2).

Positive control:

mouse brain, mouse heart, rat brain

AA Sequence:

LLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACS

Purification:

Affinity purification

Molecular weight:

Calculated MW: 106kDa Observed MW: 110kDa

Form:

Liquid

Applications:

Request info at info@sobekbio.com

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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