Product info:

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

Alternative names:

B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; CD274

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Cell membrane, Endomembrane system, Single-pass type I membrane protein

Isotype:

IgG

Immunogen:

Recombinant protein of human PD-L1/CD274.

Positive control:

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AA Sequence:

Email info@sobekbio.com for sequence

Purification:

≥95% purity by SDS-PAGE

Molecular weight:

Calculated MW: 20kDa/33kDa Observed MW: Refer to figures

Form:

Liquid

Applications:

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Dilution:

ELISA 1:500 - 1:2000 WB 1:500 - 1:2000 FC 1:50 - 1:200 Inhibition1ug/ul

Storage buffer:

Buffer: PBS with 0.09% sodium azide, 50% glycerol, pH7.4.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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