Product info:

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Alternative names:

ALS19; HER4; p180erbB4; ERBB4; HER4/ErbB4

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Cellular localisation:

Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around Y1284 of human ErbB4/HER4 (NP_005226.1).

Positive control:

A-431

AA Sequence:

PEYLS

Purification:

Affinity purification

Molecular weight:

Calculated MW: 143kDa/145kDa/146kDa Observed MW: 200kDa

Form:

Liquid

Applications:

WB (C57BL6, Mus musculus) IHC (Mus musculus) IF (Mus musculus)

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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