Product info:

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names:

LAT; LAT1; pp36; IMD52

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

Cell membrane, Single-pass type III membrane protein

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around Y171 of human LAT (NP_001014987.1).

Positive control:

Jurkat

AA Sequence:

DDYVN

Purification:

Affinity purification

Molecular weight:

Calculated MW: 24kDa/27kDa/28kDa Observed MW: 38kDa

Form:

Liquid

Applications:

Request info at info@sobekbio.com

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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