Product info:

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names:

AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1; ATM

Species reactivity:

Human, Mouse

Host:

Rabbit

Cellular localisation:

Cytoplasmic vesicle, Nucleus

Isotype:

IgG

Immunogen:

A synthetic phosphorylated peptide around S1981 of human ATM (NP_000042.3).

Positive control:

293T, NIH/3T3

AA Sequence:

EGSQS

Purification:

Affinity purification

Molecular weight:

Calculated MW: 350kDa Observed MW: 370KDa

Form:

Liquid

Applications:

WB (Homo sapiens, Mus musculus)

Dilution:

WB 1:500 - 1:2000 IF 1:50 - 1:200

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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