IL-13 can induce monocyte differentiation, enhance the expression of MHC class II molecules, inhibit the secretion of mononuclear cells induced by lps, control the inflammatory response, induce the proliferation of B cells and synthesize IgE antibodies, enhance the MHC class II molecules on the surface of B cells, CD23 And expression of CD72; synergistic IL-2 stimulates NK cells to produce IFN, thereby promoting monocyte-macrophage activation and TH1 type cellular immune response. Recently, it has also been found that IL-13 also inhibits the replication of HIV-1 in macrophages, induces IL-1RA gene expression and protein synthesis in neutrophils.