IL-12 can stimulate the proliferation of activated t cells, promote the differentiation of Th0 cells into Th1 cells; induce the cytotoxic activity of CTL and NK cells and promote their secretion of cytokines such as IFN-γ, TNF-α, GM-CSF; The expression of cells and il-2rα, tnf receptor and cd56 molecules enhances the ADCC effect on tumor cells. Due to the important role of IL-12 in anti-tumor immunity and anti-infective immunity, people have high hopes for its clinical application; especially il-12 can cooperate with il-2 to promote the production of ctl and lak cells, indicating that IL-12 and IL- 2 combined use is expected to constitute a more effective method of tumor immunotherapy.