Interleukin-36 (IL-36) was first discovered based on its homology to the IL-1 superfamily (IL-1F). IL-36 includes agonist IL. -36α, IL-36β, IL-36γ and inhibitor IL-36Ra, whose agonist mainly has pro-inflammatory function. IL-36Ra acts as a natural inhibitor of IL-36 agonist binding to IL-36R and inhibiting agonist ligands. Binding. IL-36 is biologically active in epithelial cells and specific immune cells. Its functions include cell activation, secretion of cytokines and chemokines, recruitment and activation of different immune cells, etc. Especially in psoriasis. In pathology, IL-36 has a wide range of effects. Recent research data also demonstrate the role of the IL-36 family in the physiology and pathology of the lung.