Interleukin-35 (IL-35) is a new member of the IL-12 family discovered in recent years. It is a heterodimer composed of α-chain p35 and β-chain Epstein-Barr virus-inducible gene 3 (EBI3), and receptors. IL12Rβ2 and glycoprotein 130 (gp130) bind to JAK-STAT signaling pathway and participate in a variety of inflammatory and autoimmune diseases by regulating the differentiation and function of T cells, B cells, dendritic cells and macrophages. The occurrence and development. Recent studies have found that in rheumatoid immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, polymyositis, dermatomyositis, Behcet's syndrome, Sjogren's syndrome, etc., IL-35 expression is abnormal and significant activity with disease Related.