Product overview:

PIK3C2B mouse monoclonal antibody, clone LBI2G3

Field of research:

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Summary:

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Alternative names:

C2-PI3K

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PIK3C2B

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human PIK3C2B(NP_002637) produced in HEK293T cell.

Clone:

LBI2G3

Conjugation:

Unconjugated

Gene name:

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

Symbol:

PIK3C2B

Pathway:

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000~4000, IHC 1:150, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com