Product overview:

COPS5 (JAB1) mouse monoclonal antibody, clone LBI2B12

Field of research:

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Summary:

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq]

Alternative names:

CSN5; JAB1; MOV-34; SGN5

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

COPS5

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human COPS5(NP_006828) produced in HEK293T cell.

Clone:

LBI2B12

Conjugation:

Unconjugated

Gene name:

COP9 signalosome subunit 5

Symbol:

COPS5

Pathway:

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Function:

Druggable Genome, Protease, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.76 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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