Product overview:

TIMP2 mouse monoclonal antibody, clone LBI1C4

Field of research:

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Summary:

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq]

Alternative names:

CSC-21K; DDC8

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

TIMP2

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human TIMP2(NP_003246) produced in HEK293T cell.

Clone:

LBI1C4

Conjugation:

Unconjugated

Gene name:

TIMP metallopeptidase inhibitor 2

Symbol:

TIMP2

Pathway:

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Function:

Druggable Genome, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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