Product overview:

FMR1 (FMRP ) mouse monoclonal antibody, clone LBI2C3

Field of research:

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Summary:

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]

Alternative names:

FMRP; FRAXA; POF; POF1; POFX

Species reactivity:

Human, Monkey, Mouse, Rat, Dog

Host:

Mouse

Target:

FMR1

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 26-279 of human FMR1(NP_002015) produced in HEK293T cell.

Clone:

LBI2C3

Conjugation:

Unconjugated

Gene name:

FMRP translational regulator 1

Symbol:

FMR1

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.96 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:200~1000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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