Product overview:

RFXANK mouse monoclonal antibody, clone LBI2F12

Field of research:

Antigen processing and presentation, Primary immunodeficiency

Summary:

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. [provided by RefSeq]

Alternative names:

ANKRA1; BLS; F14150_1; RFX-B

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

RFXANK

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human RFXANK(NP_604389) produced in HEK293T cell.

Clone:

LBI2F12

Conjugation:

Unconjugated

Gene name:

regulatory factor X associated ankyrin containing protein

Symbol:

RFXANK

Pathway:

Antigen processing and presentation, Primary immunodeficiency

Function:

Druggable Genome, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com