Product overview:

IDS (Iduronate 2 sulfatase) mouse monoclonal antibody, clone LBI1D9

Field of research:

Glycosaminoglycan degradation, Lysosome, Metabolic pathways

Summary:

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq]

Alternative names:

MPS2; SIDS

Species reactivity:

Human, Mouse

Host:

Mouse

Target:

IDS

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human IDS(NP_000193) produced in HEK293T cell.

Clone:

LBI1D9

Conjugation:

Unconjugated

Gene name:

iduronate 2-sulfatase

Symbol:

IDS

Pathway:

Glycosaminoglycan degradation, Lysosome, Metabolic pathways

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com