Product overview:

PTPN7 (HePTP) mouse monoclonal antibody, clone LBI3H8

Field of research:

MAPK signaling pathway

Summary:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Alternative names:

BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PTPN7

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human PTPN7(NP_542155) produced in HEK293T cell.

Clone:

LBI3H8

Conjugation:

Unconjugated

Gene name:

protein tyrosine phosphatase non-receptor type 7

Symbol:

PTPN7

Pathway:

MAPK signaling pathway

Function:

Druggable Genome, Phosphatase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.85 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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