Product overview:

PMVK mouse monoclonal antibody, clone LBI1C12

Field of research:

Metabolic pathways, Terpenoid backbone biosynthesis

Summary:

This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]

Alternative names:

HUMPMKI; PMK; PMKA; PMKASE; POROK1

Species reactivity:

Human, Rat

Host:

Mouse

Target:

PMVK

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human PMVK(NP_006547) produced in HEK293T cell.

Clone:

LBI1C12

Conjugation:

Unconjugated

Gene name:

phosphomevalonate kinase

Symbol:

PMVK

Pathway:

Metabolic pathways, Terpenoid backbone biosynthesis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.6 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com