Product overview:

CYP17A1 mouse monoclonal antibody, clone LBI3F12

Field of research:

C21-Steroid hormone metabolism, Metabolic pathways

Summary:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]

Alternative names:

CPT7; CYP17; P450C17; S17AH

Species reactivity:

Human

Host:

Mouse

Target:

CYP17A1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CYP17A1(NP_000093) peoduced in HEK293T cell.

Clone:

LBI3F12

Conjugation:

Unconjugated

Gene name:

cytochrome P450 family 17 subfamily A member 1

Symbol:

CYP17A1

Pathway:

C21-Steroid hormone metabolism, Metabolic pathways

Function:

Druggable Genome, P450

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com