Product overview:

CCM2 mouse monoclonal antibody, clone LBI5C3

Field of research:

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Summary:

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names:

C7orf22; OSM; PP10187

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CCM2

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.

Clone:

LBI5C3

Conjugation:

Unconjugated

Gene name:

CCM2 scaffold protein

Symbol:

CCM2

Pathway:

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Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.38 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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