Product overview:

BAIAP2 mouse monoclonal antibody, clone LBI1C10

Field of research:

Adherens junction, Regulation of actin cytoskeleton

Summary:

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names:

BAP2; FLAF3; IRSP53

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

BAIAP2

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human BAIAP2(NP_005331) produced in HEK293 cell.

Clone:

LBI1C10

Conjugation:

Unconjugated

Gene name:

BAR/IMD domain containing adaptor protein 2

Symbol:

BAIAP2

Pathway:

Adherens junction, Regulation of actin cytoskeleton

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com