Product overview:

PTPN1 (PTP1B) mouse monoclonal antibody, clone LBI1B4

Field of research:

Adherens junction, Insulin signaling pathway

Summary:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]

Alternative names:

PTP1B

Species reactivity:

Human, Rat

Host:

Mouse

Target:

PTPN1

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human PTPN1 (NP_002818) produced in HEK293T cell.

Clone:

LBI1B4

Conjugation:

Unconjugated

Gene name:

protein tyrosine phosphatase non-receptor type 1

Symbol:

PTPN1

Pathway:

Adherens junction, Insulin signaling pathway

Function:

Druggable Genome, Phosphatase, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.63 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com