Product overview:

PBX1 mouse monoclonal antibody, clone LBI1H5

Field of research:

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Summary:

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Alternative names:

DKFZp686B09108; MGC126627

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PBX1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human PBX1(NP_002576) produced in HEK293T cell.

Clone:

LBI1H5

Conjugation:

Unconjugated

Gene name:

PBX homeobox 1

Symbol:

PBX1

Pathway:

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Function:

Druggable Genome, Stem cell - Pluripotency, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.6 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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