Product overview:

MVK mouse monoclonal antibody, clone LBI 1D7

Field of research:

Metabolic pathways, Terpenoid backbone biosynthesis

Summary:

This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Alternative names:

LRBP; MK; MVLK; POROK3

Species reactivity:

Human

Host:

Mouse

Target:

MVK

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human MVK (NP_000422) produced in HEK293T cell.

Clone:

LBI 1D7

Conjugation:

Unconjugated

Gene name:

mevalonate kinase

Symbol:

MVK

Pathway:

Metabolic pathways, Terpenoid backbone biosynthesis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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