Product overview:

RASSF1 mouse monoclonal antibody, clone LBI8E2

Field of research:

Bladder cancer, Non-small cell lung cancer, Pathways in cancer

Summary:

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names:

123F2; NORE2A; RASSF1A; RDA32; REH3P21

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

RASSF1

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human RASSF1 (NP_009113) produced in E.coli.

Clone:

LBI8E2

Conjugation:

Unconjugated

Gene name:

Ras association domain family member 1

Symbol:

RASSF1

Pathway:

Bladder cancer, Non-small cell lung cancer, Pathways in cancer

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.87 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com