Product overview:

BCL10 mouse monoclonal antibody, clone LBI6A4

Field of research:

B cell receptor signaling pathway, T cell receptor signaling pathway

Summary:

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]

Alternative names:

c-E10; CARMEN; CIPER; CLAP; IMD37; mE10

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

BCL10

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human BCL10 (NP_003912) produced in HEK293T cell.

Clone:

LBI6A4

Conjugation:

Unconjugated

Gene name:

BCL10 immune signaling adaptor

Symbol:

BCL10

Pathway:

B cell receptor signaling pathway, T cell receptor signaling pathway

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.5 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com