Product overview:

ADSL (Adenylosuccinate Lyase) mouse monoclonal antibody, clone LBI2D10

Field of research:

Alanine, aspartate and glutamate metabolism, Metabolic pathways, Purine metabolism

Summary:

Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Alternative names:

AMPS; ASASE; ASL

Species reactivity:

Human, Monkey, Mouse, Rat, Dog

Host:

Mouse

Target:

ADSL

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human ADSL (NP_000017) produced in HEK293T cell.

Clone:

LBI2D10

Conjugation:

Unconjugated

Gene name:

adenylosuccinate lyase

Symbol:

ADSL

Pathway:

Alanine, aspartate and glutamate metabolism, Metabolic pathways, Purine metabolism

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.55 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500~2000, IHC 1:150, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com