Product overview:

Anti-DYNC1LI1 mouse monoclonal antibody, clone LBI2B6

Field of research:

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Summary:

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Alternative names:

DLC-A; DNCLI1; LIC1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DYNC1LI1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human DYNC1LI1 (NP_057225) produced in HEK293T cell.

Clone:

LBI2B6

Conjugation:

Unconjugated

Gene name:

dynein cytoplasmic 1 light intermediate chain 1

Symbol:

DYNC1LI1

Pathway:

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Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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