Product overview:

Anti-PANK2 mouse monoclonal antibody, clone LBI3H9

Field of research:

Metabolic pathways, Pantothenate and CoA biosynthesis

Summary:

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq]

Alternative names:

C20orf48; HARP; HSS; NBIA1; PKAN

Species reactivity:

Human, Monkey, Mouse, Rat, Dog

Host:

Mouse

Target:

PANK2

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human PANK2(NP_705902) produced in HEK293T cell.

Clone:

LBI3H9

Conjugation:

Unconjugated

Gene name:

pantothenate kinase 2

Symbol:

PANK2

Pathway:

Metabolic pathways, Pantothenate and CoA biosynthesis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000~2000, IHC 1:50, IF 1:100, FLOW 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com