Product overview:

Anti-USP5 mouse monoclonal antibody, clone LBI2E3

Field of research:

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Summary:

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]). [supplied by OMIM]

Alternative names:

ISOT

Species reactivity:

Human, Monkey, Mouse, Rat, Dog

Host:

Mouse

Target:

USP5

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human USP5 (NP_003472) produced in HEK293T cell.

Clone:

LBI2E3

Conjugation:

Unconjugated

Gene name:

ubiquitin specific peptidase 5

Symbol:

USP5

Pathway:

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Function:

Druggable Genome, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.45 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000~2000, IHC 1:50

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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