Product overview:

Anti-RANGAP1 mouse monoclonal antibody, clone LBI1B4

Field of research:

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Summary:

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]

Alternative names:

Fug1; RANGAP; SD

Species reactivity:

Human, Mouse, Rat, Dog

Host:

Mouse

Target:

RANGAP1

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human RANGAP1 (NP_002874) produced in HEK293T cell.

Clone:

LBI1B4

Conjugation:

Unconjugated

Gene name:

Ran GTPase activating protein 1

Symbol:

RANGAP1

Pathway:

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Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.81 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000~2000, IHC 1:50, IF 1:100, FLOW 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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