Product overview:

Anti-BIRC5/Survivin mouse monoclonal antibody, clone LBI2D9

Field of research:

Colorectal cancer, Pathways in cancer

Summary:

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Alternative names:

API4; EPR-1

Species reactivity:

Human

Host:

Mouse

Target:

BIRC5

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human BIRC5 (NP_001159) produced in HEK293T cell.

Clone:

LBI2D9

Conjugation:

Unconjugated

Gene name:

baculoviral IAP repeat containing 5

Symbol:

BIRC5

Pathway:

Colorectal cancer, Pathways in cancer

Function:

Druggable Genome, Stem cell - Pluripotency

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100, FLOW 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com