Product overview:

Anti-IFT57 (HIPPI) mouse monoclonal antibody, clone LBI2G3

Field of research:

Huntington's disease

Summary:

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1,leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

Alternative names:

ESRRBL1; HIPPI; MHS4R2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

IFT57

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human IFT57 (NP_060480) produced in HEK293T cell.

Clone:

LBI2G3

Conjugation:

Unconjugated

Gene name:

intraflagellar transport 57

Symbol:

IFT57

Pathway:

Huntington's disease

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.71 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000, IHC 1:50, IF 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com