Product overview:

Anti-ID3 mouse monoclonal antibody, clone LBI7B6

Field of research:

TGF-beta signaling pathway

Summary:

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Alternative names:

bHLHb25; HEIR-1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ID3

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human ID3 (NP_002158) produced in HEK293T cell.

Clone:

LBI7B6

Conjugation:

Unconjugated

Gene name:

inhibitor of DNA binding 3, HLH protein

Symbol:

ID3

Pathway:

TGF-beta signaling pathway

Function:

Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.75 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:50, IF 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com