Product overview:

Anti-BIRC7 (Livin) mouse monoclonal antibody, clone LBI1B10

Field of research:

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Summary:

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

Alternative names:

KIAP; LIVIN; ML-IAP; MLIAP; RNF50

Species reactivity:

Human

Host:

Mouse

Target:

BIRC7

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human BIRC7 (NP_071444) produced in HEK293T cell.

Clone:

LBI1B10

Conjugation:

Unconjugated

Gene name:

baculoviral IAP repeat containing 7

Symbol:

BIRC7

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IF 1:100, Flow 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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