Product overview:

RNF144B (IBRDC2) mouse monoclonal antibody, clone LBI10A12

Field of research:

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Summary:

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism.

Alternative names:

bA528A10.3; IBRDC2; p53RFP; PIR2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

RNF144B

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-256 of human RNF144B (NP_877434) produced in E. coli.

Clone:

LBI10A12

Conjugation:

Unconjugated

Gene name:

ring finger protein 144B

Symbol:

RNF144B

Pathway:

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Function:

Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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