Product overview:

Anti-XRCC4 mouse monoclonal antibody, clone LBI4H9

Field of research:

Non-homologous end-joining

Summary:

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.

Alternative names:

SSMED

Species reactivity:

Human

Host:

Mouse

Target:

XRCC4

Isotype:

IgG1

Immunogen:

Full-length protein expressed in 293T cell transfected with human XRCC4 expression vector

Clone:

LBI4H9

Conjugation:

Unconjugated

Gene name:

X-ray repair cross complementing 4

Symbol:

XRCC4

Pathway:

Non-homologous end-joining

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:50

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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