Product overview:

Anti-POR (Cytochrome P450 Reductase) mouse monoclonal antibody, clone LBI5B6

Field of research:

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Summary:

This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.

Alternative names:

CPR; CYPOR; P450R

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

POR

Isotype:

IgG1

Immunogen:

Full-length protein expressed in 293T cell transfected with human POR expression vector

Clone:

LBI5B6

Conjugation:

Unconjugated

Gene name:

cytochrome p450 oxidoreductase

Symbol:

POR

Pathway:

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Function:

Druggable Genome, P450, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.75 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000, IHC 1:50, IF 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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