Product overview:

FKBP1A (FKBP12) mouse monoclonal antibody, clone LBI3B3

Field of research:

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Summary:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq]

Alternative names:

FKBP-1A; FKBP-12; FKBP1; FKBP12; FKBP12-Exip3; FKBP12C; PKC12; PKCI2; PPIASE; rotamase

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

FKBP1A

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human FKBP1A (NP_000792) produced in HEK293T cell.

Clone:

LBI3B3

Conjugation:

Unconjugated

Gene name:

FKBP prolyl isomerase 1A

Symbol:

FKBP1A

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.8 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB: 1:200 - 1:1000, IHC 1:150, FLOW 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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