Product overview:

Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone LBI2B8

Field of research:

Neurotrophin signaling pathway

Summary:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Alternative names:

GP145-TrkC; TRKC; gp145(trkC)

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

NTRK3

Isotype:

IgG1

Immunogen:

Full-length protein expressed in 293T cell transfected with human NTRK3 expression vector

Clone:

LBI2B8

Conjugation:

Unconjugated

Gene name:

neurotrophic receptor tyrosine kinase 3

Symbol:

NTRK3

Pathway:

Neurotrophin signaling pathway

Function:

Druggable Genome, Protein Kinase, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:50, IF 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com