Product overview:

Anti-BUB1B (BubR1) mouse monoclonal antibody, clone LBI3C7

Field of research:

Cell cycle

Summary:

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome(APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Alternative names:

Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1

Species reactivity:

Human

Host:

Mouse

Target:

BUB1B

Isotype:

IgG1

Immunogen:

Full-length protein expressed in 293T cell transfected with human BUB1B expression vector

Clone:

LBI3C7

Conjugation:

Unconjugated

Gene name:

BUB1 mitotic checkpoint serine/threonine kinase B

Symbol:

BUB1B

Pathway:

Cell cycle

Function:

Druggable Genome, Protein Kinase, Stem cell - Pluripotency

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.75 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000 IHC 1:50 IF 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com