Product overview:

Anti-SSB mouse monoclonal antibody, clone LBI6G7

Field of research:

Systemic lupus erythematosus

Summary:

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).

Alternative names:

La; La/SSB; LARP3

Species reactivity:

Human, Monkey, Dog

Host:

Mouse

Target:

SSB

Isotype:

IgG1

Immunogen:

Full-length protein expressed in 293T cell transfected with human SSB expression vector

Clone:

LBI6G7

Conjugation:

Unconjugated

Gene name:

small RNA binding exonuclease protection factor La

Symbol:

SSB

Pathway:

Systemic lupus erythematosus

Function:

Stem cell - Pluripotency, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1.06 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000~2000, IHC 1:150, IF 1:100, IP 2ug/500ul

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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