Product overview:

SILV (Melanoma gp100) mouse monoclonal antibody, clone LBI7E3

Field of research:

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Summary:

Could be a melanogenic enzyme. Could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

Alternative names:

D12S53E; gp100; ME20; ME20-M; ME20M; P1; P100; PMEL17; SI; SIL; SILV

Species reactivity:

Human

Host:

Mouse

Target:

PMEL

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human SILV (NP_008859) produced in HEK293T cell.

Clone:

LBI7E3

Conjugation:

Unconjugated

Gene name:

premelanosome protein

Symbol:

PMEL

Pathway:

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Function:

Secreted Protein, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

FLOW 1:100, IHC: 1:150

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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