Product overview:

Anti-TRPM4 mouse monoclonal antibody, clone LBI14C3

Field of research:

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Summary:

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload

Alternative names:

hTRPM4; LTrpC4; PFHB1B; TRPM4B

Species reactivity:

Human

Host:

Mouse

Target:

TRPM4

Isotype:

IgG1

Immunogen:

Full-length protein expressed in 293T cell transfected with human TRPM4 expression vector

Clone:

LBI14C3

Conjugation:

Unconjugated

Gene name:

transient receptor potential cation channel subfamily M member 4

Symbol:

TRPM4

Pathway:

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Function:

Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.7 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000, IHC 1:50

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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