Product overview:

Anti-STAT3 mouse monoclonal antibody, clone LBI21E7

Field of research:

Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer

Summary:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokinesand growth factors, STAT family members are phosphorylated by the receptor associated kinases, andthen form homo- or heterodimers that translocate to the cell nucleus where they act astranscription activators. This protein is activated through phosphorylation in response to variouscytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This proteinmediates the expression of a variety of genes in response to cell stimuli, and thus plays a keyrole in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has beenshown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor ofthis protein. Three alternatively spliced transcript variants encoding distinct isoforms have beendescribed

Alternative names:

ADMIO; APRF; HIES

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

STAT3

Isotype:

IgG1

Immunogen:

Recombinant protein expressed in E.coli corresponding to amino acids 154-175 of human stat3

Clone:

LBI21E7

Conjugation:

Unconjugated

Gene name:

signal transducer and activator of transcription 3

Symbol:

STAT3

Pathway:

Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer

Function:

Druggable Genome, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

0.35 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB: 1:500, IHC 1:50

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com