Product overview:

Anti-HES1 mouse monoclonal antibody, clone LBI4H1

Field of research:

Maturity onset diabetes of the young, Notch signaling pathway

Summary:

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Alternative names:

bHLHb39; HES-1; HHL; HRY

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

HES1

Isotype:

IgG1

Immunogen:

Recombinant protein expressed in E.coli corresponding to amino acids 1-280 of human HES1

Clone:

LBI4H1

Conjugation:

Unconjugated

Gene name:

hes family bHLH transcription factor 1

Symbol:

HES1

Pathway:

Maturity onset diabetes of the young, Notch signaling pathway

Function:

Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000; IHC 1:50; RPPA 1:75; IF (1:100)

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com