Product overview:

Pdx1 mouse monoclonal antibody, clone LBI5D5

Field of research:

Maturity onset diabetes of the young, Type II diabetes mellitus

Summary:

Pdx1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. It is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in PDX1 gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Alternative names:

GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PDX1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human PDX1 (NP_000200) produced in E.coli.

Clone:

LBI5D5

Conjugation:

Unconjugated

Gene name:

pancreatic and duodenal homeobox 1

Symbol:

PDX1

Pathway:

Maturity onset diabetes of the young, Type II diabetes mellitus

Function:

Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:5000~10000

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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