Product overview:

CK8 (Keratin 8) mouse monoclonal antibody, clone LBI1B12

Field of research:

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Summary:

Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

Alternative names:

CARD2; CK-8; CK8; CYK8; K2C8; K8; KO

Species reactivity:

Human, Monkey, Mouse, Rat, Dog

Host:

Mouse

Target:

KRT8

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 91-381 of human CK8 (NP_002264) produced in E.coli.

Clone:

LBI1B12

Conjugation:

Unconjugated

Gene name:

keratin 8

Symbol:

KRT8

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2500~5000, IHC 1:50 - 1:150, IF 1:50 - 1:100

Storage buffer:

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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