Product overview:

GEMIN2 mouse monoclonal antibody, clone LBI4B3

Field of research:

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Summary:

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Alternative names:

SIP1; SIP1-delta

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

GEMIN2

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human GEMIN2(NP_003607) produced in E.coli.

Clone:

LBI4B3

Conjugation:

Unconjugated

Gene name:

gem nuclear organelle associated protein 2

Symbol:

GEMIN2

Pathway:

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Function:

Druggable Genome, Stem cell - Pluripotency

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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