Product overview:

ERCC8 mouse monoclonal antibody, clone LBI1G2

Field of research:

Nucleotide excision repair, Ubiquitin mediated proteolysis

Summary:

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Alternative names:

CKN1; CSA; UVSS2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ERCC8

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human ERCC8(NP_001007235) produced in E.coli.

Clone:

LBI1G2

Conjugation:

Unconjugated

Gene name:

ERCC excision repair 8, CSA ubiquitin ligase complex subunit

Symbol:

ERCC8

Pathway:

Nucleotide excision repair, Ubiquitin mediated proteolysis

Function:

Druggable Genome, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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