Product overview:

AMACR mouse monoclonal antibody, clone LBI3E10

Field of research:

Metabolic pathways, Primary bile acid biosynthesis

Summary:

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

Alternative names:

AMACRD; CBAS4; RACE; RM

Species reactivity:

Human

Host:

Mouse

Target:

AMACR

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human AMACR (NP_055139) produced in HEK293T cell.

Clone:

LBI3E10

Conjugation:

Unconjugated

Gene name:

alpha-methylacyl-CoA racemase

Symbol:

AMACR

Pathway:

Metabolic pathways, Primary bile acid biosynthesis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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